Relaxing facial muscles is an ideal way to target lines linked to repetitive facial expressions. Dynamic wrinkles—which are caused by facial activity like squinting, frowning, and smiling—can be visible even when the face is in motion. The Cassileth Plastic Surgery and Skin Care team in Beverly Hills offers JEUVEAU, XEOMIN, and DYSPORT for Los Angeles–area women and men who want a more youthful appearance without undergoing plastic surgery. Our team is driven by a focus on personalized care and a desire for patients to have all the options available for smoothing out unwanted facial fine lines and wrinkles.

There are some subtle differences between the three injectables. Each has unique properties that make it an excellent option for treating wrinkles in specific patients. The Cassileth Plastic Surgery and Skin Care team can help women and men alike discover whether JEUVEAU, XEOMIN, DYSPORT, or any other neuromodulator would be the most effective for their concerns.

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DYSPORT, XEOMIN, JEUVEAU, and BOTOX all belong to a group of wrinkle–relaxing cosmetic injectables made from botulinum toxin type A. Known as neuromodulators, they manipulate nerve activity to temporarily relax targeted facial muscles. The treatments are mainly used in the upper area of the face, around the forehead and eyes. The resulting smoother skin can last for months.

Although DYSPORT, XEOMIN, and JEUVEAU have similar effects, the Cassileth team can guide you in deciding which of their distinct features will work best for your particular needs.


Injectable neuromodulators like DYSPORT, XEOMIN, and JEUVEAU can help a person appear more youthful and refreshed by relaxing specific muscle contraction and reducing the appearance of:

Unlike plastic surgery, treatment with injectables is a fast, in-office procedure that does not require any downtime.1

How Do Neuromodulators Work?

Preparing for Injectables

Injectables are administered during a very short session at our Beverly Hills plastic surgery center, and there is little patients need to do to prepare. You may be advised to refrain from taking anti-inflammatory medications or drinking alcohol in the days before your treatment, as this may help reduce swelling and bruising at the injection site.

Your Injectables Procedure

In most cases, treatment with injectables takes less than 15 minutes, so patients can literally take a lunch break to get a more youthful look! For all three— DYSPORT, XEOMIN, and JEUVEAU—the product is administered with a fine needle directly into the muscle. Since XEOMIN does not contain the same proteins as DYSPORT and other injectable neuromodulators, it doesn't have to be refrigerated or stored in a freezer before being used. Because of this, the injections may be warmer and more comfortable.

Recovery After Injectables

Our experienced injectors work to make every treatment session as comfortable as possible. Still, patients can expect some common, temporary side effects, such as redness, headaches, and bruising and sensitivity in the treatment area.

Results for all neuromodulators can last for roughly three to four months.

What are the Differences Between DYSPORT, XEOMIN, AND JEUVEAU?


DYSPORT tends to diffuse more readily and can be effective for targeting larger areas as opposed to very small clusters of wrinkles.

DYSPORT also has the fastest onset of effects out of all the available neuromodulators, with the first signs of smoother skin potentially seen as soon as 24 hours after a treatment!

DYSPORT is a formulation derived from botulinum toxin type A (like BOTOX Cosmetic) has FDA approval for cosmetic use in minimizing moderate to severe glabellar lines (sometimes called the "elevens" or frown lines), but also has off–label uses for crow's feet and smile lines.

Research shows that patients who underwent DYSPORT treatment had a rate of satisfaction of 97%.2 DYSPORT contains lactose and cow's milk proteins, so it may not be suitable for some patients.


Unlike other injectable neurotoxins, XEOMIN does not contain preservatives or accessory proteins, such as lactose. It is made up of just one active ingredient: botulinum toxin, the key ingredient in BOTOX injections. This is why it's often dubbed "the naked injectable."

For this reason, patients who have developed a "resistance" to other neuromodulators, or who have had reactions due to their body's immune response to additives found in other options, may find XEOMIN more effective.

XEOMIN has the longest onset time for the full effect of treatment to be noticeable—five to seven days—when compared to the other neuromodulator brands. Like DYSPORT, XEOMIN is FDA approved for cosmetic use to improve the look of "elevens" or frown lines between the eyebrows. XEOMIN can also be used off-label to treat crow’s feet, lip wrinkles and fine lines, and neck banding.


In 2019, a new neuromodulator joined the lineup of wrinkle–smoothing injectables: JEUVEAU. Beverly Hills' Cassileth Plastic Surgery and Skin Care provides the newly developed neuromodulator, which has the same molecular size as BOTOX and is also made from the active ingredient botulinum toxin—believed to be the most powerful for wrinkle injections. JEUVEAU is FDA approved specifically for cosmetic use in diminishing the appearance of frown lines for a more youthful–looking face.3 It may also be used off-label to treat crow’s feet and other wrinkles and fine lines around the eye area as well as forehead lines. The name JEUVEAU is based on the French word "nouveau" (meaning "new"). It is sometimes marketed as #NEWTOX.

Who is a Good Candidate for DYSPORT, XEOMIN, AND JEUVEAU?

Frequently Asked Questions About Wrinkle Reducing Injectables

What other treatments complement DYSPORT, XEOMIN, AND JEUVEAU?

Patients who want to reduce wrinkles and lines caused by collagen loss or restore contours by elevating sagging areas may be interested in the wide range of dermal fillers available at Cassileth Plastic Surgery & Skin Care. These include the hyaluronic acid–based in the JUVEDERM and RESTYLANE® families, RADIESSE®, and poly–L–lactic acid–based SCULPTRA®. In addition to neuromodulators and fillers, chemical peels and laser skin resurfacing help to create a more even overall tone and texture while softening the appearance of fine lines.

The team at Cassileth works with you during your one–on–one consultation to create a treatment plan that is tailor made just for you!

Do men get treated with injectables?

Absolutely. Men, as well as women, may be troubled by the appearance of wrinkles and fine lines, especially those caused by repetitive facial expressions. Often referred to as “Brotox,” treatment with injectables like DYSPORT, XEOMIN, and JEUVEAU has dramatically grown in popularity among men. At Cassileth Plastic Surgery and Skin Care, our injectors are experts at applying these treatments to help men look naturally younger and more refreshed, never “overdone.”

How many treatments will I need to see results?

Results of treatment with injectables like DYSPORT, XEOMIN, and JEUVEAU are quickly visible after just a single session. These results do begin to fade after roughly four months, so many of our patients choose to come in for periodic touch-ups.

Who is a good candidate for treatment with neuromodulators?

Any adult who is frustrated by the appearance of facial wrinkles may consider treatment with neuromodulators. These treatments are not recommended for women who are pregnant or breastfeeding.

1 American Society of Plastic Surgeons. Botulinum Toxin. Available: https://www.plasticsurgery.org/cosmetic-procedures/botulinum-toxin. Accessed August 11, 2021.

2 Molina B, Grangier Y, Mole B, Ribe N, Martín Diaz L, Prager W, Paliargues F, Kerrouche N. Patient satisfaction after the treatment of glabellar lines with Botulinum toxin type A (Speywood Unit): a multi-centre European observational study. J Eur Acad Dermatol Venereol. 2015 Jul;29(7):1382-8. doi: 10.1111/jdv.12881. Epub 2014 Dec 12. PMID: 25495499. Available: https://pubmed.ncbi.nlm.nih.gov/25495499/. Accessed August 11, 2021.

3 Jeuveau [Package Insert], Santa Barbara, CA: Evolus, Inc; 2019.

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